Viagra Substances are already undergoing clinical studies for the prevention of heart failure. Scientists are going to create a combination of drugs with beta-blockers.
One reason for the pump function loss of the heart is the death of cells. It leads to the fact that the remaining cells hypertrophied expanded, walls of the chambers of the heart get thicken, and slowing reductions lead to arrhythmias. Discovery has showed that
Viagra acts on phosphodiesterase, enzymes that affect the division of cyclic guanosine monophosphate, which inhibit cell growth in hypertrophied muscles.
Viagra is off proteins PDE5 group, consisting of more than 50 individual enzymes. Each of them may become the target for the drug, especially PDE1a enzyme, inhibiting the growth of heart cells by other means. With PDE5 enzyme group damages pathways that are sensitive to calcium, which also influences the development of heart disease.
Experiments showed that mice with cardiac hypertrophy PDE1a levels increased. Inhibitor PDE1 IC86340 reduced hypertrophy by 75%.
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