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The scientists have identified the chemicals – antibiotics with a new principle of action. They may form the basis for creating the next generation of the drugs to combat pathogenic microorganisms, which gradually acquire resistance to current drugs, researchers reported in the article published in the journal Nature Chemical Biology.

Over the past 40 years, despite the extensive development of medicine industry there were opened only two new groups of chemical compounds with the ability to suppress the development of single-celled organisms, or cause their death. However, the pathogens because of the widespread use of existing antibiotics, as a result of gradual mutations they are beginning to develop resistance to drugs, greatly complicating the work of doctors.

Eric Brown (Eric Brown) and his colleagues at McMaster University in Canada used a new approach to finding chemical compounds that could destroy microorganisms. The approach foundation is based on genetic methods. With the developed technique, the researchers were able not only to very quickly test the antibacterial activity of certain compounds, but also to identify the mechanism of their effects on microbes. As a result, the scientists found a chemical compound, called MAC13243. It is able to suppress the activity of microorganisms in previously unknown ways.

The fact is that all existing antibiotics either inhibit the synthesis of the bacterial membrane, or the work of the DNA of microorganisms, or inhibit the synthesis of a key bacterial proteins. In contrast to existing antibiotics, MAC13243 protein inhibits the work LolA, which is located on the surface of the cell membrane of microorganisms and provides a binding of many important biologically active substances. "We found out that the previously passed over by other researchers' aspect of the physiology of bacteria that could actually be used to create new types of antibiotics. It gave us the opportunity to take a fresh look at the drugs problem", said Brown, as quoted by the press office of the university.