Mountain View, California branch of Vivus Inc showed outstanding results of one experimental obesity drug for loosing weight up to 15% of the body weight based on usage previous weight-loss and
epilepsy drugs in one combination. The drug should assist the people with severe obesity to lose so much weight that it improves successfully their health conditions based on old approaches for research. But the trials are subjected to confirm the time to keep the weight lost as well as to ensure the pay off the obesity problem being solved by two ways, either the behavior changed or biological way.
Attacking hormones such as leptin and ghrelin, brain chemicals such as neuropeptide Y and stopping the body from absorbing nutrients have main obstacles as Human Behavior. Why? In common, people gorge even they are full, so speed up metabolism, suppress appetite, and prevent fat absorption with drugs could be less effective as expected.
Vivus ensure that they could improve on "fen-phen" sadly-known combination carried out the market in 1997 with heart damages and occasional fatal cases of pulmonary hypertension.
Qnexa, the new Vivus drug contains safe form of
phentermine, a generic stimulant that has been in fen-phen combinations jointly with fenfluramine that nowadays is a part of Wyeth under trade names, like Redux and Pondimin. This drug definitely damage heart valves with creation of fluid that is the main symptom of pulmonary hypertension. The patients suffered from the above mentioned combination opened cases and they still have to be settled by Wyeth.
Jonson & Jonson sold the combination of phentermine with topiramate as an epilepsy drug, under the Trade name
Topamax. The combination was done by Vivus that shares approximately 80% on the news.
Phentermine is a stimulant to speed up the metabolism and topiramate is an anti-convulsant. These combinations studies with positive results to lose weight and low blood pressure even with plentiful meal.
There are the following trials results on severe obesity patients as follows: over a year the top dosage was taken to lose weight and it was gained 37 pounds equal to 14.7% of the body weight in comparison with losing 2.5% in patients taken Placebo; the patients taken lowest dosage lost 13%. The fact is that 10% of lose the body weight is enough to lower cholesterol, to reduce diabetes and fatal risks. In the USA there is approximately 60% of adult population with overweight and about 9 million people are suffering from severe obesity with Body Mass Index more than 40.
The statistics given by the USA National Institute of Health Care confirmed that obese people with Body Mass Index more than 30 have 50-100% risk for any reason death, particular with the reason with heart illnesses.
"Healthy indication of Body Mass Index is 25 for the person of six feet tall and weight of 83 kg but the person is obese with BMI of 30 with weight 100 kg and a severely obese person has BMI more than 30 with weight approximately 300 pounds," – said Eric Walsh, Editor.
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